The aim of this work was to evaluate the antibacterial activity of turmeric (Curcumalonga) seed extract and its synergy with antibiotics against Staphylococcusaureus and Escherichiacoli.Antibacterial assay was carried out against the test organisms using disc diffusion method. The results showed zone of inhibition in diameter. For ethanol extract 25mm and 15mm on Staphylococcusaureus and Escherichiacoli respectively, water extract 20mm and 10mm on S. aureus and E. coli respectively, Ciprofloxacin 24mm and 23mm on S. aureus and E. coli respectively, Ampicillin 16mm and 10mm on S. aureus and E. coli respectively. Synergy of the extracts and antibiotics on test organisms; ethanol extract and Ciprofloxacin 30mm and 20mm on Staphylococcusaureus and Escherichiacoli respectively, water extract and Ciprofloxacin 22mm and 19mm on Staphylococcusaureus and Escherichiacoli respectively. Water extract and Ampicillin 18mm and 17mm on S. aureus and E. coli respectively, Ampicillin