Sida acuta is a shrub found in the tropics. The plant has been ethno - botanically reported to be used in treatment of cancer, tumor, arthritis and fever. This study on H. pylori investigates the antimicrobial activities of various plant parts extracts of Sida acuta. The leaf (201.7g) and stem (147.9g) were cleaned, shade dried and pulverized and extracted using the Soxhlet method. Water and ethanol were used for the extraction of active ingredients from the dried powdered leaves and stems. Antimicrobial sensitivity testing was carried out at different concentrations (25mg/ml, 50mg/ml, 100mg/ml, 200mg/ml and 400mg/ml) using agar well diffusion method. McFarland method was used to standardize the inoculum (H. pylori). The zones of inhibition were measured in millimetres. At 25mg/ml only ASESA and ELESA inhibited the test organism with diameter zones of inhibition of 12mm and 8mm respectively. The highest zone of inhibition was recorded by ASESA and ESESA with zones o