This study examined the effects of Human Menopausal Gonadotrophin (Pergonal(r)) on testicular morphology of the male reproductive organ of rabbits. Twenty four (24) male rabbits between the ages of 5 – 8 months were used for this study. These male rabbits were divided into four treatment groups, with six bucks in each group. The four treatment groups were identified as: T1M (control), administered with 0.00ml Human menopausal gonadotrophin (HMG); T2M administered with 0.03ml HMG; T3M administered with 0.06ml HMG; and T4M administered with 0.09ml HMG injections. The animals were randomly assigned to the four treatment groups of HMG in a completely randomized design (CRD). Each group was further replicated three times, giving two animals per replicate. The injection was administered intramuscularly for 3 consecutive days. The testicular morphometry and reproductive organ weights were collected five days after the administration of the drug (HMG) by dissecting 2 bucks from each treatment group. The organ weights of the male reproductive organs were obtained using the sensitive weighing balance. The result showed that the male reproductive organ weight increased as level of pergonal increased and the values obtained showed that their were variations among the treatment groups. The result of this study showed an increase in the testicular organ weights of the buck. Thus care must be taken in administration of this drug to mature bucks to avoid development of certain disease such as cancer on the male reproductive organ of animals. Keywords: Effects, Human Menopausal Gonadotrophin, (Pergonal(r)), testicular morphology, male, reproductive organ, rabbits.